What is the maximum daily dosage of Thorazine that may be given to achieve a therapeutic effect?

The therapeutic dosing of Thorazine (chlorpromazine) can vary based on the condition being treated, the severity of symptoms, and the individual patient's response to the medication. In psychiatric settings, especially for severe symptoms such as those seen in schizophrenia or acute psychotic episodes, dosages can be higher to ensure efficacy.

The range of 800-1,000mg is generally recognized as an upper limit for adults especially in acute settings, where the goal is to quickly manage severe symptoms. Such high dosages are sometimes used for brief periods under close medical supervision. Doses above this range are typically not standard practice due to increased risk of side effects, including sedation, hypotension, and extrapyramidal symptoms.

In contrast, the lower ranges provided in the other choices are generally insufficient for managing severe psychotic symptoms, particularly during acute episodes where a more aggressive approach is warranted. Thus, while the maximum dosage can reach the level proposed in the correct choice, the therapeutic effect necessitates careful monitoring at this level to avoid potential adverse effects.