Which factor can exacerbate depression in a patient?

Significant life changes can exacerbate depression in a patient due to the stress and emotional turmoil they often bring. These changes may include events such as the loss of a loved one, divorce, job loss, or major transitions like moving to a new city. Such experiences can lead to feelings of sadness, anxiety, and helplessness, which can trigger or worsen depressive episodes, especially in individuals who may already be vulnerable due to personal history or mental health issues.

In contrast, strong family support can provide emotional comfort and resources that help individuals cope better with stressors. Stable employment typically offers a sense of purpose and structure, which can be protective against depression. Regular physical activity is well-documented to have mood-enhancing benefits, helping reduce symptoms of anxiety and depression by increasing endorphins and improving overall health. Thus, while these other factors can promote well-being, significant life changes often bring significant stress that can negatively impact a person's mental health.